Review ArticleInverted Papilloma of the Nasal Cavity and Paranasal SinusesMendenhall, William M. MD*; Hinerman, Russell W. MD*; Malyapa, Robert S. MD, PhD*; Werning, John W. MD†; Amdur, Robert J. MD*; Villaret, Douglas B. MD†; Mendenhall, Nancy P. MD* Author Information From the Departments of *Radiation Oncology and †Otolaryngology, University of Florida College of Medicine, Gainesville, Florida. Reprints: William M. Mendenhall, MD, 2000 SW Archer Rd., PO Box 100385, Gainesville, FL 32610-0385. E-mail: [email protected]. American Journal of Clinical Oncology 30(5):p 560-563, October 2007. | DOI: 10.1097/COC.0b013e318064c711 Buy Metrics Abstract Purpose: To discuss the treatment and outcomes of inverted papilloma of the nasal cavity and paranasal sinuses. Methods: Review of the pertinent literature. Results: Inverted papilloma is a benign, locally aggressive neoplasm that arises in the nasal cavity and is associated with squamous cell carcinoma in approximately 5% of patients. Squamous cell carcinoma may be present with inverted papilloma at the initial diagnosis or it may occur metachronously after prior treatment. Surgery is the primary treatment of inverted papilloma. The likelihood of local recurrence varies from less than 5% to over 50%, depending on the extent of resection. There is likely no significant difference in the risk of local recurrence after open compared with endoscopic resection. The probability of local recurrence and/or death from tumor is increased if inverted papilloma is associated with squamous cell carcinoma. The likelihood of cure is approximately 50% when malignancy is present and postoperative radiotherapy should be considered for the majority of patients. A small subset of patients with inverted papilloma present with incompletely resectable disease. Definitive radiotherapy using doses between 65 and 70 Gy will locally control gross disease in the majority of patients. Conclusion: The preferred treatment of inverted papilloma is surgery; postoperative radiotherapy is added if it is associated with squamous cell carcinoma. The likelihood of local recurrence after surgery for inverted papilloma may be substantial and varies with the extent of resection. Definitive radiotherapy may be used to successfully treat patients with incompletely resectable inverted papilloma. © 2007 Lippincott Williams & Wilkins, Inc.