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Role of Radiotherapy for Pleomorphic Adenoma

Hodge, C Wesley, BS*; Morris, Christopher G., MS*; Werning, John W., MD; Mendenhall, William M., MD*

American Journal of Clinical Oncology: April 2005 - Volume 28 - Issue 2 - p 148-151
doi: 10.1097/01.coc.0000144266.48387.02
Original Article: Head and Neck

The purpose of this article was to evaluate the role of radiotherapy (RT) in the treatment of pleomorphic adenoma. This is a retrospective analysis of 17 patients treated with RT alone (2 patients) or combined with surgery (15 patients). Follow up ranged from 1.8 to 27.1 years (median, 9.6 years). Local control was obtained in 8 of 10 patients (80%) with subclinical disease and 3 of 7 patients (43%) with gross disease. Overall local control was obtained in 11 of 17 patients (65%). The 5- and 10-year overall local control rates were 69% and 61%, respectively. One patient died secondary to tumor extension into the central nervous system, 1 patient had recurrence of carcinoma ex-pleomorphic adenoma and died of cancer at the primary site, 5 patients died free of disease, and 10 patients were alive at last follow up. RT is relatively effective at controlling subclinical disease in patients at high risk for developing recurrence after surgery for pleomorphic adenoma. Limited data suggest that RT may also occasionally control gross disease.

From the Departments of *Radiation Oncology and †Otolaryngology, University of Florida College of Medicine, Gainesville, Florida.

Reprints: William M. Mendenhall, MD, Department of Radiation Oncology, University of Florida Health Science Center, PO Box 100385, Gainesville, FL 32610-0385. E-mail:

© 2005 Lippincott Williams & Wilkins, Inc.