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Merkel Cell Carcinoma After Chronic Lymphocytic Leukemia

Case Report and Literature Review

Vlad, Roxana, MD*; Woodlock, Timothy J., MD*†

American Journal of Clinical Oncology: December 2003 - Volume 26 - Issue 6 - p 531-534
doi: 10.1097/01.coc.0000037108.86294.5E
Case Report

Increasing evidence supports an association of Merkel cell carcinoma (MCC) with immunodeficiency and neoplasia, and the management and outcome of these patients requires study. This report describes a 72-year-old man with newly diagnosed chronic lymphocytic leukemia (CLL) who developed MCC of his right upper extremity and died of bone marrow metastases at 8 months. In the five previously reported cases of MCC after CLL, a shorter time interval between the diagnosis of CLL and the onset of MCC was associated with a better prognosis. In contrast, in this case the near simultaneous onset of CLL and MCC was followed by a rapid, lethal outcome.

*Department of Medicine, Unity Health System, Rochester, New York, and the †Cancer Center, University of Rochester School of Medicine, Rochester, New York, U.S.A.

Reprints: Dr. T. J Woodlock, Department of Medicine, Unity Health System, 89 Genesee Street, Rochester, NY 14611, U.S.A.

© 2003 Lippincott Williams & Wilkins, Inc.