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Long-Term Survival of Patients With Advanced/Recurrent Carcinoma of Cervix and Vagina After Neoadjuvant Treatment With Methotrexate, Vinblastine, Doxorubicin, and Cisplatin With or Without the Addition of Molgramostim, and Review of the Literature

Long, Harry J. III M.D.; Rayson, Sandra M.D.; Podratz, Karl C. M.D.; Abu-Ghazaleh, Samir M.D.; Suman, Vera Ph.D.; Hartmann, Lynn C. M.D.; Levitt, Ralph M.D.; Nair, Suresh M.D.; Hatfield, Alan K. M.D.; Knost, James A. M.D.

American Journal of Clinical Oncology: December 2002 - Volume 25 - Issue 6 - p 547-551

A randomized phase III study was conducted to assess the addition of molgramostim (GM-CSF) to the combination of methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) in terms of response rate, progression-free survival, and survival in women with advanced, recurrent, or metastatic carcinoma of the cervix or vagina. Patients received four 4-week cycles of methotrexate 30 mg/m2 IV days 1, 15, 22; vinblastine 3 mg/m2 IV days 2, 15, 22; doxorubicin 30 mg/m2 IV day 2; and cisplatin 70 mg/m2 IV day 2 with or without GM-CSF 5 μg/kg every 12 hours subcutaneously days 3 to 12. They were then reevaluated for operability. Those who were not surgical candidates were offered additional chemotherapy until progression or toxicity. Those who were surgical candidates were offered surgical resection of remaining tumor followed by involved-field external beam irradiation to sites of no prior irradiation and intraoperative irradiation to sites of prior external beam irradiation. This trial closed after 36 eligible patients were entered because of poor accrual. Although more than 40% of patients on each arm received fewer than four cycles of MVAC, the clinical response rate was 78% (95% CI: 52–94%) and 50% (95% CI: 26–74%) for MVAC and MVAC + GM-CSF, respectively; the median time to progression was 10.2 and 11.8 months, respectively; and median survival was 13.8 and 16.0 months, respectively. Toxicity was substantial, with more than 40% experiencing grade III to IV leukopenia, and nearly 40% experiencing grade III to IV stomatitis. MVAC with or without GM-CSF support achieves high response rates in patients with advanced, recurrent, or metastatic cervical carcinoma despite dose reductions and deletions. Its progression-free survival and overall survival rates appear promising. These results need to be confirmed within a large randomized phase III clinical trial.

From the Mayo Clinic and Mayo Foundation (H.J.L., K.C.P., V.S., L.C.H.), Rochester, Minnesota; Allan Blair Cancer Centre (S.R.), Regina, Saskatchewan, Canada; Sioux Community Cancer Consortium (S.A.-G.), Sioux Falls, South Dakota; Meritcare Hospital CCOP (R.L.), Fargo, North Dakota; Geisinger Clinic & Medical Center CCOP (S.N.), Danville, Pennsylvania; Carle Cancer Center CCOP (A.K.H.), Urbana Illinois; and Illinois Oncology Research Association CCOP (J.A.K.), Peoria, Illinois, U.S.A.

Additional participating institutions include the following: Ochsner CCOP, New Orleans, Louisiana (Carl G. Kardinal, M.D.); Nebraska Oncology Group–Creighton University, University of Nebraska Medical Center, and Associates, Omaha, Nebraska (James A. Mailliard, M.D.); Toledo Community Hospital Oncology Program CCOP, Toledo, Ohio (Paul L. Schaefer, M.D.); Iowa Oncology Research Association CCOP, Des Moines, Iowa (Roscoe F. Morton, M.D.); and Rapid City Regional Oncology Group, Rapid City, South Dakota (Larry P. Ebbert, M.D.).

This study was conducted as a collaborative trial of the North Central Cancer Treatment Group and Mayo Clinic and was supported in part by Public Health Service grants CA-15083, CA-25224, CA-37404, CA-37417, CA-35448, CA-35195, CA-35113, CA-35272, CA-63849, CA-35415, CA-35101, and CA-35103 from the National Cancer Institute, Department of Health and Human Services.

Address correspondence and reprints requests to Dr. Harry J. Long, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, U.S.A.

© 2002 Lippincott Williams & Wilkins, Inc.