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Cutaneous Angiosarcoma of Breast After Lumpectomy, Axillary Lymph Node Dissection, and Radiotherapy for Primary Breast Carcinoma: Case Report and Review of the Literature

Mermershtain, Wilmosh M.D.; Cohen, Arnon D. M.D.; Koretz, Michael M.D.; Cohen, Yoram M.D.

American Journal of Clinical Oncology: December 2002 - Volume 25 - Issue 6 - p 597-598

Malignant neoplasms known to develop after external beam radiation include angiosarcoma. Although angiosarcoma developing in a lymphedematous arm after radical mastectomy is a well-known phenomenon, cutaneous angiosarcoma after radiotherapy for breast carcinoma has been rarely documented. Herein we present a case with cutaneous angiosarcoma that developed in a 69-year-old woman’s breast 5 years after she underwent conservative treatment to the breast: lumpectomy, axillary lymph node dissection, and radiation therapy to the breast. The possible relation of the angiosarcoma to the initial radiotherapy, early diagnosis, and treatment is discussed.

From the Departments of Oncology (W.M., Y.C.), Dermatology (A.D.C.), and Surgery (M.K.), Soroka University Medical Center, Faculty of Health Science, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Address correspondence and reprint requests to Dr. Wilmosh Mermershtain, Department of Oncology, Soroka University Medical Center, Beer Sheva, Israel.

© 2002 Lippincott Williams & Wilkins, Inc.