ArticlesPlacental Metastasis from Maternal Primitive Neuroectodermal TumorSakurai, Hideyuki, M.D.; Mitsuhashi, Norio, M.D.; Ibuki, Yoshito, M.D.; Joshita, Takashi, M.D.; Fukusato, Toshio, M.D.; Niibe, Hideo, M.D.Author Information From the Department of Radiology and Radiation Oncology (H.S., N.M., H.N.) and Department of Obstetrics and Gynecology (Y.I.), School of Medicine, Gunma University; and Japan Division of Pathology (T.J., T.F.), Gunma University Hospital, Gunma, Japan. Address correspondence and reprint requests to Dr. Hideyuki Sakurai, Department of Radiology and Radiation Oncology, School of Medicine, Gunma University, 3-39-22 Showa-machi, Maebashi, Gunma 371, Japan. American Journal of Clinical Oncology: February 1998 - Volume 21 - Issue 1 - p 39-41 Buy Abstract The occurrence of placental metastasis from maternal primitive neuroectodermal tumor (PNET) is extremely rare. A 33-year-old woman at 33 weeks' gestation was admitted to the hospital. She died of the disease on hospital day 28 because the unresectable tumor was located over a wide area of the retroperitoneum. A neonate was delivered by a caesarean section without evidence of disease and has survived to 1 year of age. Pathologically, the tumor consisted of monotonous small round cells with a high nuclear cytoplasmic ratio, including several pseudorosettes and Homer-Wright-type rosettes. On immunohistochemical examination, the tumor cells were positively stained for neuron-specific enolase. Microscopically, the placenta showed intervillous metastasis from the maternal PNET. This case may be the first one of placental metastasis from PNET ever reported in the literature. © Lippincott-Raven Publishers.