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Successful Treatment of Cytophagic Histiocytic Panniculitis with Modified CHOP-E

Cyclophosphamide, Adriamycin, Vincristine, Predonisone, and Etoposide

Matsue, Kosei, M.D.; Itoh, Mami, M.D.; Tsukuda, Koji, M.D.; Miyazaki, Kazuhiro, M.D.; Kokubo, Takeshi, M.D.

American Journal of Clinical Oncology: December 1994 - Volume 17 - Issue 6 - p 470–474
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A 27-year-old woman developed generalized subcutaneous painful nodules, fever, abnormal liver function, a bleeding tendency, and pancytopenia. Skin biopsies revealed the lobular panniculitis with a morphologically benign histiocytic infiltration with prominent phagocytosis. Leukophagocytosis and erythrophagocytosis were also present in the bone marrow. The diagnosis of cytophagic histiocytic panniculitis was made. The patient received polychemotherapy with cyclo-phosphamide, Adriamycin, and vincristine on day 1, pred-nisone on day 1–5 (modified CHOP), with the addition of ctoposide (E). This regimen was repeated 8 times every 3 weeks. The patient obtained a complete clinical remission that has lasted almost 2 years after the completion of chemotherapy. Thus we suggest modified CHOP-E chemotherapy for an effective treatment for the aggressive form of cytophagic histiocytic panniculitis.

Division of Hematology/Oncology, Departments of Medicine (K.M., M.I., K.T.), Dermatology (K.M.), and Pathology (T.K.), Kameda General Hospital, Kamogawa, Chiba 296, Japan.

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