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Sensorimotor Myeloradiculoneuropathy in Thymoma

Sridhar, Kasi S., M.D.; Cohen, Andrea B., M.D.; Bruce-Gregorios, Jocelyn H., M.D.; Ayyar, D. Ram, M.D.

American Journal of Clinical Oncology: December 1991 - Volume 14 - Issue 6 - p 487–491
Original Article: PDF Only

This is the first report describing the clinical, electrophysiological, and neuropathological findings in a patient with thymoma and sensorimotor myeloradiculoneuropathy. Degeneration of the Clarke's nucleus and posterior horns were noted in addition to segmental demyelination and variable axonal loss of the anterior and posterior roots. The segmental demyelination was more severe in the anterior roots of the lower thoracic and lumbosacral regions. A possible rare association between paraneoplastic myeloradiculoneuropathy and thymoma is suggested.

Departments of Oncology (K.S.S.), Neurology (A.B.C., D.R.A.), Pathology (J.H.B-G.) and Medicine (K.S.S.), University of Miami School of Medicine, Jackson Memorial Hospital, and Veterans Administration Medical Center, Miami, Florida, U.S.A.

© Lippincott-Raven Publishers.