NINETY-ONE PATIENTS WITH SMALL CELL CARCINOMA OF THE LUNG were given a shortened, intensive course of prophylactic cranial irradiation consisting of 2,000 rad in five fractions. The CNS relapse rate was 21%, but in only one of 91 patients was the brain the first and only site of relapse. Acute toxicities consisting of headache (16%) and nausea and vomiting (15%) were observed. Results are compared with previous results from other studies of cranial irradiation.
Department of Medicine, University of Iowa, Iowa City, Iowa.
Department of Medicine, University of Toronto, Ontario, Canada.
Department of Medicine, New York University, New York City, New York.
Department of Medicine, University of California, Irvine, California.
Department of Medicine, University of Florida, Gainesville, Florida.
Department of Radiation Therapy, Toronto General Hospital, Ontario, Canada.
National Cancer Institute, Division of Cancer Treatment, Clinical Investigations Branch, Bethesda, Maryland.
Department of Biostatistics, University of Iowa, Iowa City, Iowa.