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Chemotherapy of disseminated Seminoma with combination of cis-diamminedichloroplatinum (II) and cyclophosphamide

Mugrin, Davor, M.D.a; Whitmore, Willet F. Jr.b; Batata, Mostafac

American Journal of Clinical Oncology: January 1981 - Volume 4 - Issue 4 - p 423–428

NINE PATIENTS WITH METASTATIC SEMINOMA Who had received no prior chemotherapy were induced with a combination containing cis-platinum 120mg m21 V and cyclophamide 600mg/m21 V treatments at 4–6 weeks intervals, and then received maintenance with cyclophosphamide 600 mg,/m2 1.V. every 3–4 weeks to complete 2 years of chemotherapy. Eight patients entered complete remission: five with chemotherapy alone and three with chemotherapy and radiation or resection of residual disease. Seven patients remain in CR with a minimum follow up of 17 months. Chemotherapy is effective in treatment of metastatie seminoma.

Memorial Sloan-Kettering Cancer Center, New York, New York.

a Solid Tumor Service, Department of Medicine.

b Urology Service Department of Surgery.

c Radiation Therapy Department.

© Lippincott-Raven Publishers.