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Reliéva, a Mahonia Aquifolium Extract for the Treatment of Adult Patients With Atopic Dermatitis

Donsky, Howard MD1*; Clarke, Don MD2

doi: 10.1097/MJT.0b013e31814002c1
Original Article

This clinical study was conducted to determine the efficacy and safety of Reliéva cream in adult patients with atopic dermatitis (eczema). This was an open-label trial in 42 patients with atopic dermatitis treated for 12 weeks with Reliéva cream (a homeopathic product containing Psorberine, a proprietary Mahonia aquifolium extract). Efficacy and safety was assessed using Eczema Area and Severity Index scores and a Subject Reported Evaluation of Treatment. The results showed significant (P < 0.05) improvements with respect to Eczema Area and Severity Index scores by comparison to subjects' baseline scores. In addition, subjects responding to a posttreatment evaluation questionnaire indicated a substantial benefit when rating effectiveness, itching, and appearance as a result of using the study preparation. Reliéva cream appears to be a safe and effective treatment for adult patients with atopic dermatitis (eczema).

1Dermatology and Cosmetic Center of Rochester, Rochester, NY; and 2Lakeside Medical Association, Glendate, CA, and Providence Holy Cross Hospital, Mission Hills, CA.

This study was supported by Apollo Pharmaceuticals, Inc., Clearwater, Florida.

*Address for correspondence: Dermatology and Cosmetic Center, 1665 East Ridge Road, Rochester, NY 14621. E-mail:

© 2007 Lippincott Williams & Wilkins, Inc.