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Expression of Matrix Metalloproteinases-2/-9 is Associated With Microvessel Density in Pancreatic Cancer

Xiang, Tinghai MD1; Xia, Xiuliang MD1; Yan, Wenyan MD2,*

doi: 10.1097/MJT.0000000000000424
Original Articles

This study aimed to investigate the association of matrix-metalloproteinase (MMP)-2 and MMP-9 with microvessel density (MVD) in pancreatic cancer. The tumor tissues and para-tumor tissues of 30 patients with pancreatic cancer were pathologically examined. The normal pancreatic tissues of another 17 patients served as controls. The expression of MMP-2 and MMP-9 was examined using immunohistochemistry and scored. The association of MMP-2 and MMP-9 with the MVD values and pathological features were analyzed. The positive expression rates of MMP-2 and MMP-9 in the tumor tissues were significantly higher than those in the para-tumor tissues (P < 0.01). In normal pancreatic tissues, both MMP-2 and MMP-9 expressions were negative. The MVD values increased significantly along with higher tumor node metastasis stages (P = 0.04). The MVD values were positively correlated with MMP-2 scores (r = 0.563, P < 0.05) and MMP-9 scores (r = 0.451, P < 0.05). The expression of MMP-2 and MMP-9 is associated with angiogenesis in pancreatic cancer. MMPs might be used as prognostic factors and therapy targets for patients with pancreatic cancer.

1Department of Hepatobiliary Surgery, Binzhou People's Hospital, Binzhou, Shandong, China; and

2Section II, Department of Neurology, Binzhou People's Hospital, Binzhou, Shandong, China.

Address for correspondence: Section II, Department of Neurology, Binzhou People's Hospital. No.515, Huanghe seventh road, Binzhou, Shandong 256610, China. E-mail:

The authors have no conflicts of interest to declare.

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