Original ArticlesHypomagnesemia Among Outpatient Long-Term Proton Pump Inhibitor UsersBiyik, Murat MD1; Solak, Yalcin MD2; Ucar, Ramazan MD3; Cifci, Sami MD1,*; Tekis, Dilek MD4; Polat, İlker MD3; Göktepe, Mevlüt Hakan MD3; Sakiz, Davut MD3; Ataseven, Huseyin MD1; Demir, Ali MD1 Author Information 1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey; 2Nephrology Clinic, Karaman State Hospital, Karaman, Turkey; 3Department of Internal Medicine, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey; and 4Gastroenterology Clinic, Karaman State Hospital, Karaman, Turkey. *Address for correspondence: Gastroenteroloji Bilim Dali, İc Hastaliklari AD, Meram Tip Fakultesi, Necmettin Erbakan Universitesi, Meram, 42090 Konya, Turkey. E-mail: [email protected] The authors have no conflicts of interest to declare. American Journal of Therapeutics: January/February 2017 - Volume 24 - Issue 1 - p e52-e55 doi: 10.1097/MJT.0000000000000154 Buy Metrics Abstract Proton pump inhibitors (PPIs) are extensively prescribed drugs usually used for a long period. Recent reports linked PPI use with development of hypomagnesemia. However, there is still uncertainty regarding risk of hypomagnesemia in outpatients who were on long-term PPI use. Thus, we aimed to evaluate frequency of hypomagnesemia among a well-defined outpatient patient cohort with no other possible risk factors affecting serum magnesium levels. This was a case–control study carried out at the outpatient gastroenterology clinic of a University hospital. Patients who were on PPI therapy for at least 6 months without diuretic use and chronic kidney disease were included. Patients who were subjected to the same inclusion and exclusion criteria and not using PPI were included as control subjects. One hundred fifty-four patients and 84 control subjects were included. The mean duration of PPI use was 27.5 ± 2.5 months. Mean serum magnesium levels of PPI users and nonusers were 2.17 ± 0.20 mg/dL and 2.19 ± 0.15 mg/dL, respectively. None of the patient had a serum magnesium level below laboratory lower range of 1.7 mg/dL. Our results showed that for typical gastroenterology outpatient clinic patients with no other risk factors affecting serum magnesium levels, long-term PPI use did not affect serum magnesium levels. Copyright © 2014 Wolters Kluwer Health, Inc. All rights reserved.