Original ArticlesPharmacist's Evolving Role in the Nonopioid, Over-the-Counter, Analgesic Selection ProcessBarkin, Robert L. MBA, PharmD, FCP, DAAPM, DACFE* Author Information Departments of Anesthesiology, Pharmacology, and Family Medicine, Rush Medical College, Rush University Medical Center, Chicago, IL; and Pain Centers of North Shore University Health System, Department of Anesthesiology, Skokie Hospital, Skokie, IL; and Evanston Hospital, Evanston, IL. Address for correspondence: Department of Anesthesiology, Rush University Medical Center, 1750 West Harrison, Chicago, IL 60612. E-mail: [email protected] The authors have no conflicts of interest to declare. Selected resources for tables and drug-related information in Appendix. American Journal of Therapeutics: November/December 2015 - Volume 22 - Issue 6 - p 423-430 doi: 10.1097/MJT.0000000000000341 Buy Metrics Abstract The pharmacist provides an integral role in pain management and treatment by focusing on the selection and evaluation of analgesic agents in a process that is patient specific, patient focused, and patient centered in a personalized care plan. Counseling patients (and the families of patients) who are using acetaminophen, aspirin, and/or nonsteroidal anti-inflammatory drugs for acute musculoskeletal pain and inflammation regarding the appropriate use of these agents is a key component of the pharmacist's overall pharmacotherapeutic role. This article reviews the importance of explaining the therapeutic and nontherapeutic effects of these agents, cautions, contraindications, dosing parameters, and the avoidance of acetaminophen/aspirin and multiple nonsteroidal anti-inflammatory drug use to patients and prescribers. The article also discusses the need to evaluate the cytochrome P450 system and the patient's pharmacotherapy and comorbid disease history to identify potential drug-mediated interactions. Evaluation of patients for comorbidities, allergies, and gastrointestinal, renal, hepatic, hematologic, and cardiovascular risks is also addressed, as are essential laboratory tests and the special needs of elderly patients. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.