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Topiramate-Induced Refractory Hypokalemia

Nadkarni, Girish N. MD, MPH; Annapureddy, Narender MD; Meisels, Ira S. MD

doi: 10.1097/MJT.0b013e3182691cf5
Case Report
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Topiramate belongs to the new class of neuromodulators, which has carbonic anhydrase inhibitor activity and been associated with renal calculi. It has also been shown to cause renal potassium wasting; however, it is generally clinically insignificant. Here, we describe a case of refractory hypokalemia in a patient with severe comorbidities who was on topiramate for seizures.

Department of Medicine, Division of Nephrology, St. Luke’s-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY.

Address for correspondence: St. Luke’s-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons. 1000 Tenth Avenue, Suite 3A-02, New York, NY-10019. Email: narender.omc@gmail.com

The authors report no conflicts of interest to disclose.

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