Topiramate-Induced Refractory HypokalemiaNadkarni, Girish N. MD, MPH; Annapureddy, Narender MD; Meisels, Ira S. MDAmerican Journal of Therapeutics: September/October 2014 - Volume 21 - Issue 5 - p e157–e158 doi: 10.1097/MJT.0b013e3182691cf5 Case Report Buy Abstract Author InformationAuthors Article MetricsMetrics Topiramate belongs to the new class of neuromodulators, which has carbonic anhydrase inhibitor activity and been associated with renal calculi. It has also been shown to cause renal potassium wasting; however, it is generally clinically insignificant. Here, we describe a case of refractory hypokalemia in a patient with severe comorbidities who was on topiramate for seizures. Department of Medicine, Division of Nephrology, St. Luke’s-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY. Address for correspondence: St. Luke’s-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons. 1000 Tenth Avenue, Suite 3A-02, New York, NY-10019. Email: email@example.com The authors report no conflicts of interest to disclose. Copyright © 2014 Wolters Kluwer Health, Inc. All rights reserved.