Effect of Enhanced External Counterpulsation on Clinical Symptoms, Quality of Life, 6-Minute Walking Distance, and Echocardiographic Measurements of Left Ventricular Systolic and Diastolic Function After 35 Days of Treatment and at 1-Year Follow Up in 47 Patients With Chronic Refractory Angina PectorisKumar, Anil MD1; Aronow, Wilbert S MD2*; Vadnerkar, Aniket MD1; Sidhu, Puneet MBBS3; Mittal, Sanjay MD3; Kasliwal, Ravi R MD3; Trehan, Naresh MD3American Journal of Therapeutics: March-April 2009 - Volume 16 - Issue 2 - p 116-118 doi: 10.1097/MJT.0b013e31814db0ba Original Article Buy Abstract Author InformationAuthors Article MetricsMetrics In a prospective study, enhanced external counterpulsation (EECP) was performed for 1 hour each day for 35 days in 47 patients, mean age 61 ± 8 years, with prior coronary revascularization who had chronic refractory angina pectoris despite antianginal drugs and who were not candidates for further coronary revascularization. Compared with baseline values, EECP significantly improved anginal symptoms, dyspnea on exertion, and quality of life after 35 days of treatment (P < 0.001) and at 1-year follow up (P < 0.001). Compared with the baseline value of 653 ± 249 feet, EECP significantly improved the 6-minute walking distance to 1025 ± 234 feet after 35 days of treatment (P < 0.001) and to 1040 ± 221 feet at 1-year follow up (P < 0.001). However, EECP did not significantly affect left ventricular ejection fraction, left ventricular end-diastolic and end-systolic dimensions, left ventricular end-diastolic and end-systolic volumes, E/A ratio, isovolumic relaxation time, and deceleration time measured by two2-dimensional and Doppler echocardiography. 1Department of Medicine, Soundshore Medical Center, New Rochelle, NY; 2Cardiology Division, New York Medical College, Valhalla, NY; and 3ESCORTS Heart Institute and Research Center, New Delhi, India. *Address for correspondence: Cardiology Division, New York Medical College, Macy Pavilion, Room 138, Valhalla, NY 10595. E-mail: WSAronow@aol.com © 2009 Lippincott Williams & Wilkins, Inc.