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Bupropion-Associated QRS Prolongation Unresponsive to Sodium Bicarbonate Therapy

Wills, Brandon K DO, MS1; Zell-Kanter, Michele PharmD2*; Aks, Steven E DO3

American Journal of Therapeutics: March-April 2009 - Volume 16 - Issue 2 - p 193-196
doi: 10.1097/MJT.0b013e3180a5bd83
Case Report
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We describe a case of bupropion-associated QRS prolongation that was unresponsive to intravenous bolus therapy of sodium bicarbonate. Bupropion may cause seizures and conduction delays similar to tricyclic antidepressants in the overdose setting by an unknown mechanism.

1Department of Emergency Medicine, Madigan Army Medical Center, Tacoma, WA; and 2Section of Clinical Toxicology and 3Department of Emergency Medicine, TOXIKON Consortium, Cook County Hospital, Chicago, IL.

Poster presentation at the North American Congress of Clinical Toxicology, Seattle, Washington, September 11, 2004.

*Address for correspondence: Section of Clinical Toxicology, 1900 West Polk Street, Suite 500, Chicago, IL 60612. E-mail: nkanter@aol.com

© 2009 Lippincott Williams & Wilkins, Inc.