We describe a case of bupropion-associated QRS prolongation that was unresponsive to intravenous bolus therapy of sodium bicarbonate. Bupropion may cause seizures and conduction delays similar to tricyclic antidepressants in the overdose setting by an unknown mechanism.
1Department of Emergency Medicine, Madigan Army Medical Center, Tacoma, WA; and 2Section of Clinical Toxicology and 3Department of Emergency Medicine, TOXIKON Consortium, Cook County Hospital, Chicago, IL.
Poster presentation at the North American Congress of Clinical Toxicology, Seattle, Washington, September 11, 2004.
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