Therapeutic ReviewLycopene in Cancer Prevention and TreatmentSeren, Soley MD1; Lieberman, Ronald MD2; Bayraktar, Ulas D MD3; Heath, Elisabeth MD1,3; Sahin, Kazim PhD4; Andic, Fundagul MD5; Kucuk, Omer MD1,3*Author Information 1Department of Internal Medicine, Wayne State University, and Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, USA; 2MedImmune, Gaithersburg, Maryland, USA; 3Division of Hematology and Oncology, Wayne State University, and Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, USA; 4Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey; and 5Department of Radiation Oncology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey. *Address for correspondence: Division of Hematology and Oncology, 4100 John R, 4-HWCRC, Detroit, MI 48201. E-mail: firstname.lastname@example.org American Journal of Therapeutics: January-February 2008 - Volume 15 - Issue 1 - p 66-81 doi: 10.1097/MJT.0b013e31804c7120 Buy Metrics Abstract Dietary intake of lycopene is inversely associated with the risk of many cancers. Preclinical studies show that lycopene has potent in vitro and in vivo antitumor effects, suggesting potential preventive and therapeutic roles for the compound. However, clinical trials with lycopene have only recently been started, and available clinical data preclude firm conclusions with regard to its use in cancer prevention and treatment. Further mechanistic studies and randomized controlled clinical intervention trials with lycopene involving cancer patients are warranted. © 2008 Lippincott Williams & Wilkins, Inc.