Original ArticlesExtraction of 20(S)-Ginsenoside Rg2 from Cultured Panax notoginseng Cells In Vitro Stimulates Human Umbilical Cord Vein Endothelial Cell ProliferationXin, Xiujuan; Liu, Jianwen; Li, Xiqiang; Zhong, Jianjiang; Wei, Dongzhi* Author Information State Key laboratory of Bioreactor Engineering, Institute of Biochemistry, East China University of Science and Technology, Shanghai, P.R. China Supported by the Key Disciplinary Foundation of Shanghai. *Address for correspondence: State Key Laboratory of Bioreactor Engineering, Institute of Biochemistry, East China University of Science and Technology, Shanghai 200237, P.R. China. E-mail: [email protected] American Journal of Therapeutics 13(3):p 205-210, May 2006. | DOI: 10.1097/01.mjt.0000212706.73410.57 Buy Metrics Abstract From the cultured cells of Panax notoginseng, a kind of ginseng saponin—ginsenoside Rg2, was separated and purified, and its structure was elucidated as 6-O-[α-L-rhamnose (l→2)-β-D-glucopyranosyl]3β, 12β, 20(S)-trihydroxydammar-24-ene [20(S)-ginsenoside Rg2]. Moreover, its bioactivity stimulates human umbilical cord vein endothelial cell proliferation; the growth of the cells treated with 20(S)-ginsenoside Rg2 was 14-fold higher than that of untreated ones, and the level of the cell's plasminogen activator (PA) was also twofold higher. © 2006 Lippincott Williams & Wilkins, Inc.