Evaluation of Erectile Dysfunction Therapy in Patients Previously Nonadherent to Long-Term Medications: A Retrospective Analysis of Prescription ClaimsMcLaughlin, Trent1*; Harnett, James2; Burhani, Soraya1; Scott, Brian1American Journal of Therapeutics: November-December 2005 - Volume 12 - Issue 6 - p 605-611 doi: 10.1097/01.mjt.0000181305.44330.4a Original Articles Buy Abstract Author InformationAuthors Article MetricsMetrics Erectile dysfunction (ED) can lead to treatment noncompliance in patients taking medications for chronic health conditions. Using the Intelligent Health Repository, NDCHealth's longitudinal, United States health care claims database, we examined the impact of treating ED on adherence to long-term therapies in previously nonadherent patients. Male patients ≥18 years of age were identified who received antidepressant (AD), antihypertensive (AH), oral hypoglycemic (OHG), or lipid-lowering (LL) agents and initiated therapy with sildenafil citrate (Viagra) between January and June 2003. Treatment adherence was determined using medication possession ratios (MPRs) for the 12 months before and after the first prescription of sildenafil. Prior to initiation of therapy for ED with sildenafil, 64% of patients with comorbid medications were not adherent (MPR <0.8). Among these patients, 728 (27%) received AD, 2112 (78%) received AH, 984 (18%) received OHG, and 1078 (40%) received LL agents, with 66% of patients receiving multiple therapeutic classes. During the 12-month period after the first sildenafil prescription, patients had a significant increase in medication adherence compared with the 12 months before the first prescription of sildenafil (P < 0.0001). The percentage of patients who became adherent (MPR ≥0.8) with medications after sildenafil treatment was from 22% to 36%. With the exception of the LL group, there was a significant relationship between ≥3 sildenafil prescriptions and change in MPR (P < 0.05). Patients aged ≥65 years had similar improvement in MPR as patients ≤65 years. Treatment of ED with sildenafil improved adherence in patients taking common long-term medications who were previously nonadherent. 1NDCHealth, Phoenix, AZ; 2Pfizer Inc, New York, NY, USA. *Address for correspondence: NDCHealth, 2394 East Camelback Road, Phoenix, AZ 85016. E-mail: Trent.McLaughlin@ndchealth.com Funding for this research project provided by Pfizer Inc. © 2005 Lippincott Williams & Wilkins, Inc.