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Bioavailability and Pharmacokinetics of Magnesium After Administration of Magnesium Salts to Humans

Ranade, V. V.1*; Somberg, J. C.2

Symposium

Therapeutically, magnesium salts represent an important class of compounds and exhibit various pharmacologic actions. Examples of magnesium salts are ionic magnesium and magnesium citrate in nephrolithiasis, magnesium salicylate in rheumatoid arthritis, magnesium hydroxide as an antacid as well as a cathartic, and magnesium mandelate as urinary antiseptic. Various anions attached to the cation magnesium, such as oxide, chloride, gluconate, and lactate, affect the delivery of the amounts of elemental magnesium to the target site and thereby produce different pharmacodynamic effects. This review examines the bioavailability and pharmacokinetics of various magnesium salts and correlates pharmacodynamic action with the structure-activity relationship.

1Rush-Presbyterian-St. Luke's Medical Center, Chicago; 2American Institute of Therapeutics, Lake Bluff, IL.

*Address for correspondence: Rush-Presbyterian–St. Luke's Medical Center, Department of Clinical Pharmacology, 2242 W. Harrison Street, Tech 2000, Suite 260, Chicago, IL 60612-3515; e-mail: jsomberg@rush.edu

© 2001 Lippincott Williams & Wilkins, Inc.