Original Articles: PDF OnlyComparison of 7 Versus 10 Days of Antibiotic Therapy for Hospitalized Patients with Uncomplicated Community-Acquired Pneumonia A Prospective, Randomized, Double-Blind StudySiegel, Robert E.1,3,4; Alicea, Margarita1; Lee, Alice2; Blaiklock, Robert2Author Information 1 Department of Pulmonary and Critical Care Medicine, and 2Pharmacy Service, Bronx Veterans Affairs Medical Center, Bronx; and 3Department of Pulmonary and Critical Care Medicine, and 4Department of Medicine, Mount Sinai School of Medicine, New York City, New York. American Journal of Therapeutics: July 1999 - Volume 6 - Issue 4 - p 217-222 Buy Abstract The objective of this study was to compare the outcome of 7 versus 10 days of antibiotic therapy for inpatients with moderately severe community-acquired pneumonia (CAP). A prospective, randomized, double-blind study with a follow-up period of 42 days was conducted. Fifty-two veterans were treated with 2 days of cefuroxime at 750 mg intravenously every 8 hours followed by group 1, 8 days oral therapy, and group 2, 5 days oral therapy followed by 3 days of placebo. Oral therapy consisted of cefuroxime axetil at 500 mg every 12 hours. No difference was seen in cure rates: 20 of 22 (90.9%) patients in group 1 and 21 of 24 (875%) patients in group 2. There were no late recurrences. Potential US cost-savings is $27.2 million. Inpatients with moderately severe CAP can be treated with 2 days of intravenous antibiotics followed by 5 additional days of oral antibiotics. Longer treatment duration prolongs the cost of care, without increasing the cure rate or decreasing the pneumonia recurrence rate. © 1999 Lippincott Williams & Wilkins, Inc.