Article: PDF OnlyTOXICITY ASSOCIATED WITH A PROLONGED HALF-LIFE OF PHENYTOIN IN A 97-YEAR-OLD WOMAN BEZOAR FORMATION? CASE REPORT AND CLINCAL PATHOLOGICAL CONFERENCEFreedman, Michael D.1; Sencil, Samuel K.2Author Information 1 Sinai Hospital of Baltimore and The Johns Hopkins University School of Medicine, Baltimore, MD USA; and 2Childrens Hospital of Baltimore, Baltimore, MD USA. American Journal of Therapeutics: September 1997 - Volume 4 - Issue 9 - p 327-332 Buy Abstract Phenytoin metabolism is best described using nonlinear (Michaelis-Menton) kinetics. When calculated pharmacokinetic values, including half life and clearance, do not correspond to measured variables, alternative reasons must be sought. We present an interesting case of phenytoin toxicity and suggest that formation of a bezoar may be one possible answer to prolonged toxicity. © Williams & Wilkins 1997. All Rights Reserved.