Article: PDF OnlyNONSTEROIDAL ANTI-INFLAMMATORY DRUGS AND ASPIRIN A COMPARISON OF THE ANTIPLATELET EFFECTSCheng, Jen-Chueh1; Siegal, Lori B.2; Katari, Bhanumathi1; Traynoff, Stephanie A.3; Ro, Jae O.3Author Information 1Department of Medicine,2 Division of Rheumatology. Department of Medicine, and3Department of Laboratory Medicine, North Chicago Veterans Affairs Medical Administration and The Finch University of Health Sciences, The Chicago Medical School, North Chicago, IL., USA. American Journal of Therapeutics: February 1997 - Volume 4 - Issue 2 - p 62-65 Buy Abstract Antiplatelet effects of common analgesics were assessed in vitro. The Streck Platelet Aggregation Test Kit (Omaha, NE) was used to measure percent platelet aggregation in response to sodium arachidonate, collagen, adenosine diphosphate, and ristocetin in patients on various analgesics. In comparison with the control group, the response to arachidonate and collagen of ibuprofen (86% vs. 33% and 55% vs. 23%), naproxen (86% vs. 43% and 55% vs. 29%), indomethacin (86% vs. 26% and 55% vs. 17%), and aspirin (86 vs. 21% and 55 vs. 23%) all demonstrated a significant yet comparable reduction in platelet aggregation (p < 0.01). Because of the comparable antiplatelet effects of aspirin and NSAIDs, the additional benefits of daily aspirin in those patients on chronic and consistent NSAID therapy must be reconsidered. © Williams & Wilkins 1997. All Rights Reserved.