Frishman William H.; Nurenberg, Michael; Spiegel, AdamAmerican Journal of Therapeutics: June 1996 Therapeutic Review: PDF Only Buy Abstract Psychoactive medications, including antipsychotic, anxiolytic, antidepressant, and antimanic drugs, are commonly used in cardiovascular and internal medicine practice. Many of these drugs have adverse effects on the cardiovascular system, and some agents interact unfavorably with medications being used to treat cardiac disease. Newer psychoactive agents used to treat psychosis and/or depression appear to have a more favorable profile of cardiovascular adverse effects, but they need to be evaluated in patients with known cardiac disorders. © Williams & Wilkins 1996. All Rights Reserved.