Original ArticleAlzheimer Aβ Vaccination of Rhesus Monkeys (Macaca Mulatta)Gandy, Sam MD, PHD*; DeMattos, Ron B PHD†; Lemere, Cynthia A PHD‡; Heppner, Frank L MD§; Leverone, Jodi BS‡; Aguzzi, Adriano MD, PHD§; Ershler, William B MD, PHD¶; Dai, Jinlu PHD∥; Fraser, Paul PHD**; Hyslop, Peter St. George MD, PHD**; Holtzman, David M MD†; Walker, Lary C PHD††; Keller, Evan T DVM, PHD∥Author Information From the *Farber Institute for Neurosciences at Thomas Jefferson University, Philadelphia, PA; †Washington University, St. Louis, MO; ‡Harvard Medical Institutes and Brigham & Women’s Hospital Center for Neurological Diseases, Boston, MA; §University of Zurich, Zurich, Switzerland; ¶Institute for Advanced Studies in Aging and Geriatric Medicine, Washington, DC; ∥Department of Laboratory Animal Medicine, University of Michigan, Ann Arbor, MI; **Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada; and ††Yerkes National Primate Research Center, Emory University, Atlanta, GA. Received for publication June 24, 2003; accepted November 26, 2003. This work was supported by the National Institute of Neurological Diseases and Stroke. Presented in part at the 2nd International Conference on Immunology and Ageing, June 14–16, 2002; published in Mech Ageing Devel. 2003;125:149–151. Reprints: Sam Gandy, MD, PhD, Farber Institute for Neurosciences at Thomas Jefferson University, 900 Walnut St, Suite 467, Philadelphia, PA 19107 (e-mail: [email protected]). Alzheimer Disease & Associated Disorders: January-February-March 2004 - Volume 18 - Issue 1 - p 44-46 Buy Abstract Recent preliminary data suggest that vaccination with Alzheimer Aβ might reduce senile plaque load and stabilize cognitive decline in human Alzheimer disease. To examine the mechanisms and consequences of anti-Aβ-antibody formation in a species more closely related to humans, rhesus monkeys (Macaca mulatta) were vaccinated with aggregated Aβ1-42. Immunized monkeys developed anti-Aβ titers exceeding 1:1000, and their plasma Aβ levels were 5- to 10-fold higher than the plasma Aβ levels observed in monkeys vaccinated with aggregated amylin. These data support the use of nonhuman primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer Aβ. © 2004 Lippincott Williams & Wilkins, Inc.