Original ArticlesTrends in Alzheimer Disease Mortality Among American Indian and Alaska Native People Between 2011 and 2019Amiri, Solmaz DDes*; Jiang, Luohua PhD†; Manson, Spero M. PhD‡; Buchwald, Dedra S. MD* Author Information *Institute for Research and Education to Advance Community Health (IREACH), Elson S. Floyd College of Medicine, Washington State University, Seattle, WA †Department of Epidemiology and Biostatistics, Susan and Henry Samueli College of Health Sciences, University of California, Irvine, CA ‡Department of Community and Behavioral Health, Centers for American Indian and Alaska Native Health, University of Colorado, Aurora, CO This work was funded by the University of Colorado Denver/National Institute on Minority Health and Health Disparities (U54MD000507, PI: Spero Manson). S.A. was supported by a subcontract from the University of Colorado Denver. D.S.B., L.J., and S.M.M. were supported by the National Institute on Minority Health and Health Disparities (U54MD000507). D.S.B. was funded by grants from the National Institute of Aging (P01AG066584, P50AG005136). Reprints: Solmaz Amiri, DDes, Institute for Research and Education to Advance Community Health (IREACH), Elson S. Floyd College of Medicine, Washington State University, 1100 Olive Way, Suite 1200, Seattle, WA 98101 (e-mail: [email protected]). Alzheimer Disease & Associated Disorders 37(2):p 93-99, April–June 2023. | DOI: 10.1097/WAD.0000000000000555 Buy Metrics Abstract Purpose: The number of American Indian and Alaska Native (AI/AN) people living with dementia is expected to increase 5-fold by 2060. Social determinants of health may explain disparities in the incidence of Alzheimer disease (AD) but remain largely overlooked. Methods: We examined the time trend of AD mortality rates and associations of the percentage of AI/ANs, density of primary care physicians and neurologists, area deprivation index, rurality, and Indian Health Service region with AD mortality in 646 purchased/referred care delivery area counties. Results: AD mortality rates significantly increased over time. Counties with higher concentrations of AI/AN people had lower AD mortality. More deprived counties had 34% higher AD mortality compared with less deprived counties. AD mortality was 20% lower in nonmetro counties than in metro counties. Conclusions: Findings have implications for prioritizing areas where more resources for AD care, education, or outreach are needed. Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.