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The Alzheimer's Disease Centers' Uniform Data Set (UDS): The Neuropsychologic Test Battery

Weintraub, Sandra PhD*; Salmon, David PhD; Mercaldo, Nathaniel MS; Ferris, Steven PhD§; Graff-Radford, Neill R. MD; Chui, Helena MD; Cummings, Jeffrey MD; DeCarli, Charles MD**; Foster, Norman L. MD††; Galasko, Douglas MD; Peskind, Elaine MD‡‡; Dietrich, Woodrow BS; Beekly, Duane L. PhD; Kukull, Walter A. PhD; Morris, John C. MD§§

Alzheimer Disease & Associated Disorders: April-June 2009 - Volume 23 - Issue 2 - p 91-101
doi: 10.1097/WAD.0b013e318191c7dd
Original Articles

The neuropsychologic test battery from the Uniform Data Set (UDS) of the Alzheimer's Disease Centers (ADC) program of the National Institute on Aging consists of brief measures of attention, processing speed, executive function, episodic memory, and language. This paper describes development of the battery and preliminary data from the initial UDS evaluation of 3268 clinically cognitively normal men and women collected over the first 24 months of utilization. The subjects represent a sample of community-dwelling, individuals who volunteer for studies of cognitive aging. Subjects were considered “clinically cognitively normal” based on clinical assessment, including the Clinical Dementia Rating scale and the Functional Assessment Questionnaire. The results demonstrate performance on tests sensitive to cognitive aging and to the early stages of Alzheimer disease in a relatively well-educated sample. Regression models investigating the impact of age, education, and sex on test scores indicate that these variables will need to be incorporated in subsequent normative studies. Future plans include: (1) determining the psychometric properties of the battery; (2) establishing normative data, including norms for different ethnic minority groups; and (3) conducting longitudinal studies on cognitively normal subjects, individuals with mild cognitive impairment, and individuals with Alzheimer disease and other forms of dementia.

*Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL

Alzheimer's Disease Research Center, University of California San Diego, San Diego, CA

National Alzheimer's Coordinating Center, University of Washington

‡‡Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine and VA Northwest Network Mental Illness, Research, Education and Clinical Center, Seattle WA

§Alzheimer's Disease Center, New York University School of Medicine, New York, NY

Mayo Clinic-Jacksonville, Jacksonville, FL

Health Consultation Center, University of Southern California

Katherine and Benjamin Kagan Alzheimer's Disease Treatment Program, University of California Los Angeles, Los Angeles

**Alzheimer's Disease Center, University of California Davis, Martinez, CA

††Department of Neurology, Center for Alzheimer's Care, Imaging and Research, University of Utah, Salt Lake City, UT

§§Alzheimer's Disease Research Center, Washington University, St Louis, MO

Supported by National Institute on Aging (NIA) grant (U01 AG016976) to the National Alzheimer's Coordinating Center, University of Washington, Seattle, WA.

Reprints: Sandra Weintraub, PhD, Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, 320 E. Superior, Searle 11-467, Chicago, IL 60611 (e-mail:

Received for publication February 18, 2008; accepted June 16, 2008

© 2009 Lippincott Williams & Wilkins, Inc.