*Division of Neurosurgery, University Surgical Centre
†Memory Ageing and Cognition Center, National University Health System
Departments of ‡Biochemistry
#Pharmacology
∥Clinical Imaging Research Centre, Yong Loo Lin School of Medicine, National University of Singapore
**Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore
§Department of Neurology, National Cerebral and Cardiovascular Center, Suita, Osaka Prefecture, Japan
¶Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
Institutional ethics approval by the Domain Specific Review Board (DSRB) was obtained before the conduct of the study. Written informed consent was obtained from all patients. Consent for patients with dementia was provided by their legal representative as approved by the institutional ethics board. The study was conducted in accordance with the Declaration of Helsinki.
M.J.R.L. contributed to the study concept, analysis, and interpretation of data, as well as drafting and revision of the manuscript for content. J.T. contributed to the revision of the manuscript for content. B.G. contributed to the acquisition of data and revised the manuscript for content. T.T. contributed to the acquisition of data and revised the manuscript for content. A.R. contributed to the acquisition of data and revised the manuscript for content. H.A.V. contributed to the acquisition of data and revised the manuscript for content. C.C. contributed to the study concept and revision of the manuscript for content. S.H. contributed to the study concept, interpretation of data, as well as revision of the manuscript for content.
Supported by the National Medical Research Council (NMRC) of Singapore (NMRC/CG/NUHS/2010, NMRC/CG/013/2013, NMRC/CIRG/1485/2018), Center Grant SEED Funding (R-184-000-294-511), and the Yong Loo Lin School of Medicine Aspiration Fund.
The authors declare no conflicts of interest.
Reprints: Saima Hilal, MD, PhD, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Level 4, Block MD3, 16 Medical Drive, Singapore 117600, Singapore (e-mail: [email protected]).
