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When Decrease Aβ1-42 in CSF May Not Mean Alzheimer's Disease

Insights From Two Case Reports With Early Onset Dementia

Ladeira, Filipa, MD*; Cação, Gonçalo, MD; Correia, Ana P., MD; Pinto, Pedro S., MD; Cavaco, Sara, PhD§; Melo-Pires, Manuel, PhD; Alonso, Isabel, PhD¶,#; Taipa, Ricardo, MD†,∥

Alzheimer Disease & Associated Disorders: October-December 2018 - Volume 32 - Issue 4 - p 359–363
doi: 10.1097/WAD.0000000000000248

*Department of Neurology, Egas Moniz Hospital—Centro Hospitalar de Lisboa Ocidental

Departments of Neurology


§Neuropsychology Unit

Portuguese Brain Bank, Neuropathology Unit, Santo António Hospital—Centro Hospitalar do Porto

UnIGENe and CGPP, Institute for Celular and Molecular Biology (IBMC)

#Institute for Health Investigation and Innovation, Oporto University, Porto, Portugal

The authors declare no conflicts of interest.

Reprints: Filipa Ladeira, MD, Departments of Neurology, Egas Moniz Hospital, Rua da Junqueira 126, 1349-019 Lisbon, Portugal (e-mail:

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