Review ArticlesDriving Ability Evaluation and Rehabilitation for People With Alzheimer’s Disease and Related DementiasLiu, Ziming PhD*; Grant, Jordan BS*; Simpson, Skylar P. BS*; Khattak, Asad PhD†; Anderson, Joel G. PhD‡; Gao, Zhiming PhD§; Zhao, Xiaopeng PhD* Author Information *Department of Mechanical, Aerospace, and Biomedical Engineering, Tickle College of Engineering †Department of Civil and Environment Engineering ‡College of Nursing, The University of Tennessee, Knoxville §Oak Ridge National Laboratory, Oak Ridge, TN The authors declare no conflicts of interest. Reprints: Xiaopeng Zhao, PhD, Department of Mechanical, Aerospace, and Biomedical engineering, Tickle College of Engineering, The University of Tennessee, Knoxville, TN. Alzheimer Disease & Associated Disorders 36(4):p 374-381, October–December 2022. | DOI: 10.1097/WAD.0000000000000524 Buy Metrics Abstract Worldwide, it is estimated that around 50 million older adults have Alzheimer’s disease and related dementias (ADRD). Cognitive deficits associated with ADRD may affect a driver’s perception and decision-making and potentially cause safety concerns. Despite much research, there lacks a comprehensive cognitive evaluation to determine the driving capability of a person with ADRD and it is unclear what are the most effective training and interventions that help to enhance driving performance for these individuals. The purpose of this article is to conduct a comprehensive literature survey to review and summarize studies of driving performance evaluation and intervention for people with ADRD and discuss perspectives for future studies. Although many studies have investigated the correlations between driving behaviors and cognitive performances for people with ADRD, it remains unclear how driving behaviors and cognitive performances are associated with psychophysiological measures. We discussed the need to develop regular driving evaluation and rehabilitation protocol for people with ADRD. We also highlighted the potential benefit to combine driving tests with psychophysiological measures to assist in characterizing personalized cognitive evaluation in the behavioral evaluation process. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.