Original ArticlesScreening for Dementia and Cognitive Decline in Adults With Down Syndrome A Novel Approach Using the Informant Questionnaire on Cognitive Decline in the ElderlyPrado Mattar, Guilherme MD*,†; Uchida, Ricardo R. MD, PhD†; Haddad, Glenda G. MD‡; Shiozawa, Pedro MD, PhD†; Rebouças da Silva, Maria de Fátima BSW*; Hoexter, Marcelo Q. MD, PhD§; Busatto, Geraldo F. MD, PhD‡,∥; de Campos Bottino, Cassio M. MD, PhD‡; Fonseca, Luciana M. MD, PhD‡,¶; Forlenza, Orestes V. MD, PhD* Author Information Laboratories of *Neuroscience (LIM-27) ∥Psychiatric Neuroimaging (LIM-21) ‡Old Age Research Group (PROTER) §Obsessive-Compulsive Spectrum Disorders Program, Departamento e Instituto de Psiquiatria HCFMUSP, Faculdade de Medicina da Universidade de São Paulo †Department of Mental Health, Santa Casa School of Medical Sciences, São Paulo, Brazil ¶Department of Community and Behavioral Health, Washington State University, Spokane, WA This study was funded by the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, São Paulo Research Foundation; Grant nos. 2013/11571-9 and 2016/22123-5) and the Brazilian Instituto Nacional de Biomarcadores em Neuropsiquiatria (INBioN, National Institute for Biomarkers in Neuropsychiatry), under the auspices of the Brazilian Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, National Council for Scientific and Technological Development; Grant no. 465412/2014-9) and FAPESP (Grant no. 14/50873-3), receiving additional funding from CNPq (Grant nos. 429079/2018-4 and 301629/2018-8). The authors declare no conflicts of interest. Reprints: Guilherme Prado Mattar, MD, Instituto de Psiquiatria, Rua Dr. Ovídio Pires de Campos, 785, 3º andar, CEP 05403-000 São Paulo, Brazil (e-mail: [email protected]). Alzheimer Disease & Associated Disorders: April–June 2022 - Volume 36 - Issue 2 - p 162-167 doi: 10.1097/WAD.0000000000000495 Buy Metrics Abstract Objective: The aim was to examine the psychometric properties of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) as a diagnostic tool to screen for dementia in aging individuals with Down syndrome (DS). Methods: This was a cross-sectional study of 92 individuals with DS 30 y or above of age) evaluated with the IQCODE. Using the informant questionnaire of the Cambridge Examination for Mental Disorders of Older People with Down’s Syndrome and Others with Intellectual Disabilities, we divided the subjects into 3 diagnostic groups: stable cognition; prodromal dementia; and dementia. The ability of the IQCODE to discriminate between diagnostic groups was analyzed by calculating the areas under the receiver operator characteristic curves (AUCs). Results: The optimal IQCODE cutoffs were 3.14 for dementia versus stable cognition (AUC=0.993; P<0.001) and 3.11 for prodromal dementia+dementia versus stable cognition (AUC=0.975; P<0.001), with sensitivity/specificity/accuracy of 100%/96.8%/97.3%, and 93.3%/91.9%/92.4%, respectively. The IQCODE showed a weak-to-moderate correlation with cognitive performance (P<0.05). Conclusion: The IQCODE is a useful tool to screen for cognitive decline in individuals with DS and is suitable for use in a primary care setting. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.