Brief ReportsLong-term Neuropsychiatric Complications and 18F-FDG-PET Hypometabolism in the Brain From Prolonged Infection of COVID-19Yu, Allen T. MD, PhD*; Absar, Nicole M. MD†,‡ Author Information *Medical Scientist Training Program †Department of Psychiatry and Behavioral Health ‡Stony Brook Center of Excellence for Alzheimer’s Disease, Stony Brook University, Stony Brook, NY The authors declare no conflicts of interest. Reprints: Allen T. Yu, MD, PhD Fellow, Stony Brook University, Advanced Specialty Care, 500 Commack Road Suite 102, Commack, NY 11725 (e-mail: [email protected]). Alzheimer Disease & Associated Disorders: April–June 2022 - Volume 36 - Issue 2 - p 173-175 doi: 10.1097/WAD.0000000000000485 Buy Metrics Abstract It is becoming increasingly clear that the worldwide outbreak of severe acute respiratory syndrome coronavirus 2 will have long-term negative consequences. Some patients report functional complaints long after recovery from coronavirus disease-2019 (COVID-19), which include fatigue, breathlessness, heart palpitations, loss or alteration of taste and smell, and problems with attention, memory, and cognition. However, the long-term complications for those patients who had severe symptoms and prolonged hypoxia during their course of their hospital stay is still unknown. We report 2 patients with confirmed diagnoses of COVID-19 who experienced prolonged infection and developed rapid progressive dementia following COVID-19 pneumonia after a follow-up period of 5 to 10 months. As these cases may become more prevalent over time, we should learn to recognize the early signs of long-term COVID-19 complications in those who are especially vulnerable to neurocognitive decline. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.