Brief ReportsParosmia in Right-lateralized Semantic Variant Primary Progressive Aphasia A Case ReportJoo, Jae Young MD*; Kim, Hyug-Gi PhD†; Lee, Kyung Mi MD, PhD†; Ko, Seok Hoon MD‡; Rhee, Hak Young MD, PhD§; Park, Key-Chung MD, PhD*; Lee, Jin San MD, PhD*Author Information Departments of *Neurology †Radiology ‡Emergency Medicine, Kyung Hee University Hospital §Department of Neurology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, South Korea J.Y.J., H.-G.K. contributed equally to this work. The authors declare no conflicts of interest. Reprints: Jin San Lee, MD, PhD, Department of Neurology, Kyung Hee University Hospital, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, South Korea (e-mail: [email protected]). Alzheimer Disease & Associated Disorders: April–June 2021 - Volume 35 - Issue 2 - p 160-163 doi: 10.1097/WAD.0000000000000429 Buy SDC Metrics Abstract Parosmia, defined as the distorted perception of an odor stimulus, has been reported to be associated with head trauma, upper respiratory tract infections, sinonasal diseases, and toxin/drug consumption. To date, little is known about parosmia in right-lateralized semantic variant primary progressive aphasia. A 60-year-old right-handed man presented with a 2-year history of parosmia and prosopagnosia. Brain magnetic resonance imaging demonstrated severe atrophy of the right anterior and mesial temporal lobe, particularly in the fusiform cortex and the regions known as the primary olfactory cortex. 18F-fluorodeoxyglucose position emission tomography showed asymmetric hypometabolism of the bilateral temporal lobes (right > left). We clinically diagnosed him with right-lateralized semantic variant primary progressive aphasia. As the right hemisphere is known to be more involved in the processing of pleasant odors than the left hemisphere, we speculate that the unique manifestation of parosmia observed in this patient might be associated with the lateralization of the olfactory system. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.