Original ArticlesAssociation Between GlycA and Cognitive Function Cross-Sectional Results From the ELSA—Brasil StudyCalice-Silva, Viviane MD, PhD*,†; Suemoto, Claudia K. MD, PhD MSc†,‡; Brunoni, Andre R. MD, PhD†,§; Bensenor, Isabela M. MD, PhD†; Lotufo, Paulo A. MD, PhD†Author Information *Pro-rim Foundation, Joinville †Center for Clinical and Epidemiologic Research, Hospital Universitario, University of São Paulo ‡Division of Geriatrics §Department of Psychiatry, University of São Paulo Medical School, Sao Paulo, Brazil V.C.-S. participated in the study design, statistical analysis, interpretation of the results, and drafting of the article. C.K.S. participated in the design of the study, statistical analysis, interpretation of the results, and review of the article. I.M.B. conceived the ELSA-Brasil study, participated in the interpretation of the results, and revised the article. P.A.L. conceived the ELSA-Brasil study, participated in the study design, statistical analysis, interpretation of the results, and revised the article. All authors read and approved the final version of the manuscript. The ELSA-Brasil baseline study was supported by the Brazilian Ministry of Health (Science and Technology Department) and the Brazilian Ministry of Science and Technology and CNPq-National Research Council) (Grants# 01 06 0010.00 RS, 01 06 0212.00 BA, 01 06 0300.00 ES, 01 060278.00 MG, 01 06 0115.00 SP, 01 06 0071.00 RJ). The authors declare no conflicts of interest. Reprints: Claudia K. Suemoto, MD, PhD, MSc, University of Sao Paulo Medical School, Av. Doutor Arnaldo, 455, Room 1353, São Paulo 01346-903, Brazil (e-mail: [email protected]). Alzheimer Disease & Associated Disorders: April–June 2021 - Volume 35 - Issue 2 - p 128-134 doi: 10.1097/WAD.0000000000000431 Buy SDC Metrics Abstract Inflammation is associated with poor cognitive performance. GlycA is a novel marker of systemic inflammation, but information on GlycA and cognition is scarce. We aimed to evaluate the association between GlycA and cognitive performance in a large sample from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). In this cross-sectional study, participants with GlycA measured at baseline were included. Cognitive function was evaluated using the word list test, the trail-making test, and the semantic and phonemic verbal fluency tests. The association of GlycA with cognitive performance was investigated using linear regression models adjusted for sociodemographic and clinical variables. A total of 4327 participants were analyzed (mean age=51.5±9.0 y old, 54% were female, 60% white). The mean GlycA was 414.9±69.8 µmol/L. Higher GlycA levels were associated with lower global cognitive performance, even after adjustments for confounders and C-reactive protein. Higher GlycA levels were associated with lower performance in language and executive function domains (language: β=−0.005, 95% confidence interval CI=−0.010, −0.001, P=0.01; and executive function: β=−0.005, 95% confidence interval=0.009, −0.001, P=0.02]. GlycA was associated with worse cognitive performance in the ELSA-Brasil study, independent of C-reactive protein levels. GlycA may be a potential biomarker for cognitive impairment. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.