Brief ReportsComparison of Amyloid in Cerebrospinal Fluid, Brain Imaging, and Autopsy in a Case of Progressive Supranuclear PalsyKim, Kyung Hye MD*; Seo, Jae Deuk MD*; Kim, Eun Soo MD†; Kim, Hyang-Sook MSc‡; Jeon, Sumin BSc*; Pak, Kyoungjune MD§; Lee, Myung Jun MD*; Lee, Jae-Hyeok MD∥; Lee, Young Min MD¶; Lee, Kangyoon MD¶; Shin, Jin-Hong MD∥; Ko, Jun Kyeung MD#; Jung, Na-Yeon MD∥; Lee, Jae Meen MD#; Yoon, Jin A. MD**; Hwang, Chungsu MD††; Ahn, Jae-Woo MSc††; Sung, Suk BSc‡‡; Spina, Salvatore MD§§; Seeley, William W. MD§§; Choi, Kyung-Un MD††; Huh, Gi Yeong MD∥∥; Kim, Eun-Joo MD*Author Information Departments of *Neurology †Anesthesia and Pain Medicine §Nuclear Medicine ¶Psychiatry #Neurosurgery **Rehabilitation Medicine, Pusan National University Hospital, Pusan National University School of Medicine and Biomedical Research Institute, Busan ‡Research Institute for Convergence of Biomedical Science and Technology ∥Department of Neurology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital Departments of ††Pathology ‡‡Anatomy ∥∥Forensic Medicine, Pusan National University School of Medicine, Yangsan, Republic of Korea §§Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA Supported by a fund (2018-ER6204-00) by Research of Korea Centers for Disease Control and Prevention, Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2016R1D1A3B01007733) and a clinical research grant from Pusan National University Hospital in 2020. The authors declare no conflicts of interest. Reprints: Eun-Joo Kim, MD, Department of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, 179 Gudeok-ro, Seo-gu, Busan 49241, Republic of Korea (e-mail: firstname.lastname@example.org). Alzheimer Disease & Associated Disorders: July-September 2020 - Volume 34 - Issue 3 - p 275-277 doi: 10.1097/WAD.0000000000000396 Buy Metrics Abstract Cerebrospinal fluid (CSF) amyloid-beta 1-42 (Aβ1-42) and amyloid positron emission tomography (PET) are the 2 main Alzheimer disease amyloid biomarkers that have been validated in neuropathologically confirmed Alzheimer disease cases. Although many studies have shown concordance of amyloid positivity or negativity between CSF Aβ1-42 and amyloid PET, several studies also reported discrepancies between these 2 Aβ biomarkers. We conducted a comparison of CSF Aβ1-42 level, amyloid PET, and autopsy findings in a case with progressive supranuclear palsy in which biomarker acquisition and postmortem pathologic examination were conducted almost at the same time. Our case with antemortem CSF Aβ1-42 (+)/amyloid PET (−) who was pathologically confirmed with Aβ pathology in the cerebral cortex may indicate CSF Aβ1-42 is more sensitive for assessing in vivo Aβ than amyloid PET. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.