Original ArticlesThe Effectiveness of Small-group Community-based Information Sessions on Clinical Trial Recruitment for Secondary Prevention of Alzheimer’s DiseaseTarrant, Sarah D. MSW*,†; Bardach, Shoshana H. PhD‡; Bates, Kendra BS*,†; Nichols, Heather BS*,†; Towner, Jacqueline*,†; Tamatha, Clay*,†; Caban-Holt, Allison PhD*,†,§; Van-Eldik, Linda J. PhD*,†,∥; Murphy, Richard R. MD*,†,¶; Sperling, Reisa MD#,**; Jicha, Gregory A. MD, PhD*,†,¶Author Information *University of Kentucky Alzheimer Disease Center †Sanders-Brown Center on Aging Departments of ‡Gerontology §Behavioral Science ∥Anatomy and Neurobiology ¶Neurology, University of Kentucky Colleges of Medicine & Public Health, Lexington, KY #Massachusetts Alzheimer Disease Research Center **Department of Neurology, Harvard Medical School, Boston, MA Supported by NIH/NIA P30 AG028383 and U19AG010483. R.S. is the Principal Investigator for the Alzheimer Cooperative Study Group A4 trial, which is funded by a public-private-philanthropic partnership, including National Institute on Aging, Eli Lilly and Co., Avid, CogState, Alzheimer’s Association, and other philanthropic organizations. G.A.J. is a site investigator for the Alzheimer Cooperative Study Group engaged in the A4 trial. The remaining authors declare no conflicts of interest. Reprints: Gregory A. Jicha, MD, PhD, Sanders-Brown Centre on Aging, University of Kentucky College of Medicine, 800 South Limestone St., Lexington, KY 40536-0230 (e-mail: email@example.com). Alzheimer Disease & Associated Disorders: April–June 2017 - Volume 31 - Issue 2 - p 141-145 doi: 10.1097/WAD.0000000000000151 Buy Metrics Abstract Effective and practical recruitment strategies are needed to ensure successful recruitment into the Alzheimer disease clinical trials. To facilitate successful recruitment for the NIH-sponsored A4 (Anti-Amyloid treatment in Asymptomatic Alzheimer’s disease, NCT02008357) trial for the secondary prevention of Alzheimer disease, we developed a small-group community information session to attract and recruit potential research participants. After a successful media campaign, 213 participants were screened through telephone for eligibility, identifying 127 potential participants. Participants were given the option of a traditional one-on-one recruitment session or a small-group session. One-on-one recruitment was performed for 15 participants requesting this procedure, and yielded an overall recruitment rate of 67% (n=10). Substantially more individuals (n=112, 88%) requested small-group sessions to learn about the study. After attending the small-group informational sessions, 98% of potential participants self-reported a greater understanding of the study; and the recruitment rate from these sessions was 90%. Small-group sessions not only improved recruitment success rates, but also contributed to significantly shorter median time for consent processes (20 vs. 60 min) and reduced staff time spent on persons not recruited. Small-group education programs are an effective strategy for enhancing recruitment success and facilitating practical recruitment into clinical trials with high recruitment demands. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.