Original ArticlesAntidepressant Use in the Elderly Is Associated With an Increased Risk of DementiaWang, Chenkun PhD*,†; Gao, Sujuan PhD*,†,‡; Hendrie, Hugh C. MB, ChB, DSc‡,§,∥; Kesterson, Joe MA∥; Campbell, Noll L. PharmD‡,∥,¶; Shekhar, Anantha MD, PhD§; Callahan, Christopher M. MD‡,∥,#Author Information Departments of *Biostatistics §Psychiatry #Medicine, Indiana University School of Medicine †Richard M. Fairbank School of Public Health, Indiana University ∥Regenstrief Institute Inc. ‡Indiana University Center for Aging Research, Indianapolis ¶Department of Pharmacy Practice, Purdue University School of Pharmacy, West Lafayette, IN Supported by National Institutes of Health (NIH) grants R24 MH080827, K24 AG024078, R01 AG019181, and P30 AG10133. C.W. and S.G. had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. The authors declare no conflicts of interest. Reprints: Chenkun Wang, PhD, Vertex Pharmaceuticals Inc., 50 Northern Ave, Boston, MA 02210 (e-mail: [email protected]). Alzheimer Disease & Associated Disorders: April–June 2016 - Volume 30 - Issue 2 - p 99-104 doi: 10.1097/WAD.0000000000000103 Buy Metrics Abstract A retrospective cohort study was conducted including 3688 patients age 60 years or older without dementia enrolled in a depression screening study in primary care clinics. Information on antidepressant use and incident dementia during follow-up was retrieved from electronic medical records. The Cox proportional hazard models were used to compare the risk for incident dementia among 5 participant groups: selective serotonin re-uptake inhibitors (SSRI) only, non-SSRI only (non-SSRI), mixed group of SSRI and non-SSRI, not on antidepressants but depressed, and not on antidepressants and not depressed. SSRI and non-SSRI users had significantly higher dementia risk than the nondepressed nonusers (hazard ratio [HR]=1.83, P=0.0025 for SSRI users and HR=1.50, P=0.004 for non-SSRI users). In addition, SSRIs users had significantly higher dementia risk than non-users with severe depression (HR=2.26, P=0.0005). Future research is needed to confirm our results in other populations and to explore potential mechanism underlying the observed association. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.