Original ArticlesUsing the WHOQOL-BREF in Persons With Dementia: A Validation StudyLucas-Carrasco, Ramona PhD, MD, MPH*,†; Skevington, Suzanne M. BSc, PhD, CPsychol, ARSM, FBPsS‡; Gómez-Benito, Juana PhD†,§; Rejas, Javier MD∥; March, Jaume PhD¶Author Information *CRE Alzheimer, Salamanca †Department of Methodology of the Behavioral Sciences University of Barcelona §Institute for Brain, Cognition and Behavior (IR3C), University of Barcelona, Barcelona ∥Health Outcomes Research Department, Medical Unit, Pfizer Spain, Alcobendas, Madrid ¶Institut de Recerca Biomèdica de Lleida, IRBLLEIDA, Lleida, Spain ‡WHO Centre for the Study of Quality of Life and Department of Psychology, University of Bath, Bath, UK Pfizer sponsored the field trial work for this study and funds were used to pay interviewers at each participating center. No other financial interests were involved. The authors declare no conflicts of interest. The study was approved by the Ethics Committee at the Autonomous University of Barcelona. Dr Lucas-Carrasco and Dr March had full access to the data and were responsible for performing the data analysis, interpreting results, and preparing the draft manuscript. Professors Skevington and Gómez-Benito, and Dr Rejas reviewed the results and contributed to the drafting of the final manuscript by commenting on earlier drafts. Dr Lucas-Carrasco, Dr March, and Prof. Gómez-Benito are members of the research team assembled by the Generalitat de Catalunya 2009-SGR822. Reprints: Ramona Lucas-Carrasco, MD, PhD,MPH, CRE Alzheimer, Salamanca, Cordel de Merinas de Chamberí, 117, Salamanca 37008, Spain (e-mail: Lucas.Ramona@gmail.com). Received July 20, 2010 Accepted November 30, 2010 Alzheimer Disease & Associated Disorders: October-December 2011 - Volume 25 - Issue 4 - p 345-351 doi: 10.1097/WAD.0b013e31820bc98b Buy Metrics Abstract Increasing evidence suggests that persons with early dementia can give reliable and valid assessments about their own quality of life (QOL), thereby improving accuracy, and reducing the need for proxy informants. The objective of this study was to examine QOL in persons diagnosed with dementia (Diagnostic and Statistical Manual of Mental Disorder-IV) using a battery of subjective assessments including the new World Health Organization Quality of Life (WHOQOL-BREF). Persons with mild-to-moderate dementia (n=104) were recruited and interviewed at 6 Spanish centers to obtain sociodemographic information, health perceptions, depressive symptoms (Geriatric Depression Scale 15-item version), functional ability (Barthel Index), generic QOL (WHOQOL-BREF), and specific QOL (DEMQOL-28). Analysis was performed using classical psychometric methods. Internal consistency reliability for the WHOQOL-BREF domains ranged from moderate (0.54 for social) to good (0.79 for psychological). Test-retest reliability (intraclass correlation) ranged from moderate (0.51 for psychological) to good (0.70 for physical). Associations were confirmed between WHOQOL-BREF domains with DEMQOL-28, Geriatric Depression Scale 15-item version, and Barthel dimensions. With regard to contrasting groups' differences, WHOQOL-BREF scores significantly differentiated between healthy and unhealthy and depressed and nondepressed participants. This study is the first to report on the use of the WHOQOL-BREF in persons with mild-to-moderate dementia. These results indicate that it is a useful tool in assessing these groups, as it includes important dimensions commonly omitted from other dementia measures. © 2011 Lippincott Williams & Wilkins, Inc.