Original ArticlesNeuropsychiatric Profiles in DementiaJohnson, David K. PhD*,†; Watts, Amber S. PhD*,‡; Chapin, Benjamin A. BA†; Anderson, RaeAnn BA†; Burns, Jeffrey M. MD§Author Information *Gerontology Center †Department of Psychology ‡Center for Research Methods and Data Analysis, University of Kansas, Lawrence §Department of Neurology, University of Kansas School of Medicine, Kansas City, Kansas Supported by U01 AG016976, NS058252, AG029615, AG09009, and AG033673 from the National Institute on Aging, Bethesda, MD. The authors declare no conflicts of interest. Reprints: David K. Johnson, PhD, Gerontology Center, 1000 Sunnyside Avenue, Suite 3093, University of Kansas, Lawrence, Kansas 66045 (e-mail: email@example.com). Received March 12, 2010 Accepted November 19, 2010 Alzheimer Disease & Associated Disorders: October-December 2011 - Volume 25 - Issue 4 - p 326-332 doi: 10.1097/WAD.0b013e31820d89b6 Buy Metrics Abstract We compared patterns of neuropsychiatric symptoms across 4 dementia types [Alzheimer disease (AD), vascular dementia (VAD), dementia with Lewy bodies (DLB), and Parkinson disease dementia], and 2 mixed groups (AD/VAD and AD/DLB) in sample of 2,963 individuals from the National Alzheimer's Coordinating Center Uniform Data Set between September 2005 and June 2008. We used confirmatory factor analysis to compare neuropsychiatric symptom severity ratings made by collateral sources on the Neuropsychiatric Inventory Questionnaire for people with Clinical Dementia Rating scores of 1 or higher. A 3-factor model of psychiatric symptoms (mood, psychotic, and frontal) was shared across all dementia types. Between-group comparisons revealed unique neuropsychiatric profiles by dementia type. The AD group had moderate levels of mood, psychotic, and frontal symptoms whereas VAD exhibited the highest levels and Parkinson disease dementia had the lowest levels. DLB and the mixed dementias had more complex symptom profiles. Depressed mood was the dominant symptom in people with mild diagnoses. Differing psychiatric symptom profiles provide useful information regarding the noncognitive symptoms of dementia. © 2011 Lippincott Williams & Wilkins, Inc.