Original ArticlesPrognostic Factors for Weight Loss Over 1-year Period in Patients Recently Diagnosed With Mild Alzheimer DiseaseHansen, Marie-Louise H. MSc*; Waldorff, Frans B. PhD*,†; Waldemar, Gunhild MD, DMSc*Author Information *Memory Disorders Research Group, Department of Neurology, Rigshospitalet, Copenhagen University Hospital †Department and Research Unit of General Practice, Institute of Public Health, Centre of Health and Society, University of Copenhagen, Copenhagen, Denmark Reprints: Gunhild Waldemar, MD, DMSc, Department of Neurology, Memory Disorders Research Group, Section 2082, Rigshospitalet, Copenhagen University Hospital, 9 Blegdamsvej, Copenhagen 2100 Denmark (e-mail: firstname.lastname@example.org). Received December 7, 2009 Accepted October 1, 2010 Alzheimer Disease & Associated Disorders: July-September 2011 - Volume 25 - Issue 3 - p 269-275 doi: 10.1097/WAD.0b013e3182096624 Buy Metrics Abstract The aim of the study was to identify prognostic factors for weight loss in patients recently diagnosed with mild Alzheimer disease (AD), with special emphasis on the patients' social participation and living arrangements. The data used in this study was part of the Danish Alzheimer Intervention StudY. The patients were home-living patients with a clinical diagnosis, within the past 12 months, of probable AD or mixed AD; age ≥50 years; mini-mental state examination score ≥20; informed consent; and data available at 1-year follow-up. In total, 268 patients were included. We used a cut off of 4% in 1 year for defining weight loss. The mean age at inclusion was 76.1 years. Sixty-six patients (24.6%) lost more than 4% of their body weight during the study period. A logistic regression showed that an increase of 1 baseline body mass index point significantly increased the odds of weight loss by 9%. Furthermore, the results suggested a trend that for men, living alone was a risk factor for losing weight, whereas for women living with somebody was associated with a higher risk. However, further studies are pertinent within this area. As weight loss is a predictor of mortality in patients with AD, clinicians should be aware of prognostic social indicators to prevent or halt a potential negative development. © 2011 Lippincott Williams & Wilkins, Inc.