Original ArticlesCortical Thinning in Verbal, Visual, and Both Memory-predominant Mild Cognitive ImpairmentKim, Min-Jeong MD*; Im, Kiho PhD†; Lee, Jong-Min PhD‡; Park, Aram MA§; Chin, Juhee MA*; Kim, Geon Ha MD*; Kim, Jong Hun MD∥; Roh, Jee Hoon MD¶; Seo, Sang Won MD, PhD*; Na, Duk L. MD*Author Information *Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine Departments of ‡Biomedical Engineering §Neurology, Hanyang University, Seoul ∥Department of Neurology, National Health Insurance Corporation Ilsan Hospital, Goyang, Republic of Korea †Division of Newborn Medicine, Children's Hospital of Boston, Harvard Medical School, Boston, MA ¶Department of Neurology, Washington University School of Medicine, St Louis, MO Supported by a grant from the Korean Healthcare Technology R&D Project, Ministry for Health, Welfare, and Family Affairs, Republic of Korea (A050079), a Korean Science and Engineering Foundation (KOSEF) NRL program grant funded by the Korean government (MEST; R0A-2007-000-20068-0), and a Samsung Medical Center Clinical Research Development Program grant (CRL-108011 & CRS 110-14-1). Reprints: Sang Won Seo, MD, PhD, Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, Seoul 135-710, Republic of Korea (e-mail: email@example.com). Received June 2, 2010 Accepted November 7, 2010 Alzheimer Disease & Associated Disorders: July-September 2011 - Volume 25 - Issue 3 - p 242-249 doi: 10.1097/WAD.0b013e3182076d31 Buy Metrics Abstract The amnestic form of mild cognitive impairment (aMCI) is likely a precursor of Alzheimer disease (AD). Both verbal and visual memory tests are used in the diagnosis of aMCI; however, it is unknown which type of test is superior at predicting the underlying pathologic changes associated with AD. In this study, we compared the topography of cortical thinning among 3 subtypes of patients with aMCI: 33 patients with predominant verbal memory impairment (verbal-aMCI), 35 with predominant visual memory impairment (visual-aMCI), and 56 with both verbal and visual memory-predominant impairment (both-aMCI), and 143 patients with normal cognition. As a result, patients with verbal-aMCI showed cortical thinning in the left anterior and medial temporal regions compared with individuals with normal cognition, while those with visual-aMCI did not show significant cortical thinning. The cortical thinning areas of both-aMCI group overlapped those of verbal-aMCI but were more widespread involving the bilateral temporal regions. These findings suggest that the verbal-aMCI and both-aMCI are more likely to be a precursor of AD than visual-aMCI, and that both-aMCI may be more advanced subtype than verbal-aMCI on the spectrum from MCI to AD. © 2011 Lippincott Williams & Wilkins, Inc.