Original ArticlesRisk of Decline in Functional Activities in Dementia With Lewy Bodies and Alzheimer DiseaseGill, Dawn P. PhD*,†; Koepsell, Thomas D. MD, MPH*,†,‡; Hubbard, Rebecca A. PhD§,∥; Kukull, Walter A. PhD*,†Author Information *National Alzheimer's Coordinating Center Departments of †Epidemiology ‡Health Services §Biostatistics, University of Washington ∥Group Health Research Institute, Seattle, WA Sources of support: Fellowship LAF 95193 from the Canadian Institutes of Health Research and Grant U01 AG016976 from the National Institute of Aging. Reprints: Dawn P. Gill, PhD, National Alzheimer's Coordinating Center, 4311 11th Avenue NE, Suite 300, Seattle, WA 98105 (e-mail: email@example.com). Received May 3, 2010 Accepted September 26, 2010 Alzheimer Disease & Associated Disorders: January-March 2011 - Volume 25 - Issue 1 - p 17-23 doi: 10.1097/WAD.0b013e3182037edf Buy Metrics Abstract We examined the risk of 1-year decline in 4 everyday activities in patients with dementia with Lewy bodies (DLB), relative to patients with Alzheimer disease (AD). Data were from the National Alzheimer's Coordinating Center, gathered from 32 Alzheimer's Disease Centers. Participants (n=1880) were: aged 60+ years, demented with a primary clinical diagnosis of probable AD or DLB, and had a global Clinical Dementia Rating of 0.5 to 2. The activities were measured with the Functional Activities Questionnaire. In modified Poisson regression models adjusted for demographics, baseline activity, years from symptom onset, cognitive impairment, and comorbidities; DLB participants aged 67 to 81 years had 1.5 to 2 times increased risk of decline in performing basic kitchen tasks, engaging in games/hobbies, and paying attention/understanding, relative to AD participants of the same age (P<0.05). There was no significant difference between AD and DLB participants beyond this age range. For decline in ability to go shopping alone, there was also no significant difference between AD and DLB participants. In summary, the functional course of DLB, relative to AD, may depend on the age of the patient. These findings may provide anticipatory guidance to families and healthcare providers, which may be useful in the planning of care strategies. © 2011 Lippincott Williams & Wilkins, Inc.