Original ArticlesAwareness of Cognitive Deficits in Older Adults With Cognitive-impairment-no-dementia (CIND): Comparison With Informant ReportGreenop, Kathryn R. PhD*,†; Xiao, Jianguo MD, PhD‡; Almeida, Osvaldo P. MD, PhD*,§,∥; Flicker, Leon MBBS, PhD*,¶,♯; Beer, Christopher MBBS*,¶,♯; Foster, Jonathan K. D.Phil†,**,††; van Bockxmeer, Frank M. PhD‡‡,§§; Lautenschlager, Nicola T. MD*,§,∥∥Author Information †Division of Population Sciences, Telethon Institute for Child Health Research, Center for Child Health Research, University of Western Australia, Subiaco *WA Centre for Health & Ageing §School of Psychiatry and Clinical Neurosciences ¶School of Medicine and Pharmacology ‡‡School of Pathology and Laboratory Medicine, University of Western Australia ‡Epidemiology Branch ††Neurosciences Unit, Department of Health Western Australia §§Cardiovascular Genetics Laboratory, Division of Laboratory Medicine, Royal Perth Hospital ∥∥Department of Psychiatry, Academic Unit for Psychiatry of Old Age, St Vincent's Health, University of Melbourne, Melbourne, Victoria ♯Department of Geriatric Medicine, Royal Perth Hospital **School of Psychology & Speech Pathology, Curtin University ∥Department of Psychiatry, Royal Perth Hospital, Perth, Australia This study was funded by the National Health and Medical Research Council of Australia (NH&MRC), Project Grant number 353566. Reprints: Kathryn R. Greenop, PhD, Telethon Institute for Child Health Research, 100 Roberts Road Subiaco, WA, 6008, Australia (e-mail: email@example.com). Received November 25, 2009 Accepted August 13, 2010 Alzheimer Disease & Associated Disorders: January-March 2011 - Volume 25 - Issue 1 - p 24-33 doi: 10.1097/WAD.0b013e3181f81094 Buy Metrics Abstract Impaired awareness of cognitive deficits is a common symptom of dementia, but its prognostic importance in people with cognitive impairment-no dementia (CIND) is uncertain. In this study, we examined whether community volunteers with CIND and reduced awareness had worse cognitive performance and cognitive decline over 18 months than CIND participants with intact awareness or healthy controls. We recruited 92 participants with CIND and 91 healthy controls with their respective informants. We used discrepancy scores (informant minus participant) on the Anosognosia Questionnaire for Dementia and Dysexecutive Questionnaire to ascertain participants' awareness of their cognitive performance. The main cognitive outcome variable was the Alzheimer Disease Assessment Scale: Cognitive Section. Bivariate correlations showed no relationship between the awareness measures and cognitive performance or decline. Overall, CIND participants' ratings of cognitive deficits correlated significantly with their Alzheimer Disease Assessment Scale: Cognitive Section score after 18-months (for Anosognosia Questionnaire for Dementia, r=0.45, P <0.001) and showed a stronger relationship with cognitive performance than informant ratings. These results indicate that reduced awareness of deficit may be uncommon in community volunteer samples with CIND. In addition, self-report of cognitive complaints may be at least as useful as informant report when screening community-dwelling older adults at risk of cognitive decline and dementia. © 2011 Lippincott Williams & Wilkins, Inc.