Original ArticlesRegional Myo-inositol Concentration in Mild Cognitive Impairment Using 1H Magnetic Resonance Spectroscopic ImagingSiger, Małgorzata MD, PhD* †; Schuff, Norbert PhD*; Zhu, Xiaoping MD, PhD*; Miller, Bruce L. MD‡; Weiner, Michael W. MD*Author Information *Center for Imaging of Neurodegenerative Diseases, Veterans Administration Medical Center ‡Department of Neurology, University of California, San Francisco, CA †Department of Neurology, Medical University of Lodz, Lodz, Poland Małgorzata Siger was supported by a grant from Polish Foundation of Science. Reprints: Małgorzata Siger, MD, PhD, Department of Neurology, Medical University of Lodz, Kopcińskiego 22, 90-153 Lodz, Poland (e-mail: email@example.com). Received for publication December 6, 2007; accepted July 12, 2008 Alzheimer Disease & Associated Disorders: January-March 2009 - Volume 23 - Issue 1 - p 57-62 doi: 10.1097/WAD.0b013e3181875434 Buy Metrics Abstract The goal was to assess regional patterns of metabolite abnormalities in mild cognitive impairment (MCI) and Alzheimer disease (AD) patients using proton magnetic resonance spectroscopy imaging at 1.5 Tesla. Fourteen MCI, 17 AD, and 16 healthy control (HC) subjects were studied. MCI was associated with higher myo-inositol (mIn) concentration in right parietal white matter compared with HC and lower mIn levels in frontal white matter compared with AD. AD was associated with higher mIn concentration in frontal and parietal white matter compared with HC. N-acetylaspartate (NAA) concentration of white matter was similar in all groups, whereas NAA concentration of gray matter showed a trend toward lower values in the right parietal lobe in AD compared with MCI and HC. A mIn increase in white matter in absence of significant NAA reduction suggests that mIn is a more robust and sensitive marker of white matter pathology in AD and MCI than NAA. Furthermore, the dissociation between mIn and NAA alterations in white matter could provide important information regarding the role of glial and neuronal damage in MCI and AD. © 2009 Lippincott Williams & Wilkins, Inc.