Original ArticlesApolipoprotein E e4 Allele is Associated With More Rapid Motor Decline in Older PersonsBuchman, Aron S. MD* †; Boyle, Patricia A. PhD* ‡; Wilson, Robert S. PhD* † ‡; Beck, Todd L. MS§; Kelly, Jeremiah F. MD* ∥; Bennett, David A. MD* †Author Information *Rush Alzheimer's Disease Center, Armour Academic Facility Departments of †Neurological Sciences ‡Behavioral Science ∥Internal Medicine §Rush Institute of Healthy Aging, Rush University Medical Center, Chicago, IL Supported by National Institute on Aging grants R01AG17917, R01AG24480, and K23 AG23040, the Illinois Department of Public Health, and the Robert C. Borwell Endowment Fund. Reprints: Aron S. Buchman, MD, Rush Alzheimer's Disease Center, Armour Academic Facility, Rush University Medical Center, Chicago, IL 60612 (e-mail: Aron_S_Buchman@rush.edu). Received for publication January 19, 2008; accepted July 13, 2008 Alzheimer Disease & Associated Disorders: January-March 2009 - Volume 23 - Issue 1 - p 63-69 doi: 10.1097/WAD.0b013e31818877b5 Buy Metrics Abstract We tested the hypothesis that apolipoprotein E allele status predicts the rate of motor decline in the elderly. Eight hundred seventy-six older participants without dementia underwent baseline and annual motor testing for up to 10 years. In a generalized estimating equation controlling for age, sex, and education, motor function declined by about 0.03 U/y. The presence of ε4 allele was associated with a 2-fold increase in rate of motor decline [ε4 allele×time: estimate=−0.027 (SE 0.012, P=0.025)]. The association of ε4 allele with motor decline persisted even after controlling for cognitive status, race, body mass index, vascular risk factors, and diseases. Further analyses suggested that the association of ε4 with motor decline was for the most part explained by the association between ε4 allele and change in muscle strength. These results suggest that the presence of ε4 allele is a risk factor for more rapid motor decline in the elderly. © 2009 Lippincott Williams & Wilkins, Inc.