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Diagnostic Criteria for the Behavioral Variant of Frontotemporal Dementia (bvFTD): Current Limitations and Future Directions

Rascovsky, Katya PhD*; Hodges, John R. MD; Kipps, Christopher M. MD; Johnson, Julene K. PhD*; Seeley, William W. MD*; Mendez, Mario F. MD, PhD§; Knopman, David MD; Kertesz, Andrew MD; Mesulam, Marsel MD; Salmon, David P. PhD**; Galasko, Douglas MD** ††; Chow, Tiffany W. MD‡‡; DeCarli, Charles MD§§; Hillis, Argye MD, PhD∥∥; Josephs, Keith MD; Kramer, Joel H. PhD*; Weintraub, Sandra PhD; Grossman, Murray MD¶¶; Gorno-Tempini, Maria-Luisa MD, PhD*; Miller, Bruce M. MD*

Alzheimer Disease & Associated Disorders: October-December 2007 - Volume 21 - Issue 4 - p S14-S18
doi: 10.1097/WAD.0b013e31815c3445
Original Articles

The most widely established diagnostic criteria for the behavioral variant of frontotemporal dementia have now been in use for almost a decade. Although consensus criteria have provided a much needed standard for frontotemporal dementia research, a growing body of evidence suggests that revisions are needed to improve their applicability. In this article, we discuss the limitations of current diagnostic criteria and propose the establishment of an international consortium to revise diagnostic and research criteria for the behavioral variant of frontotemporal dementia.

*Memory and Aging Center, University of California, San Francisco

§Departments of Neurology and Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles

**Department of Neurosciences

††VA Medical Center, University of California, San Diego, CA

MRC Cognition and Brain Sciences Unit, Cambridge

Cognitive Disorders Group, Wessex Neurological Centre, Southampton, UK

Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN

Department of Clinical Neurological Sciences, St Joseph's Hospital, University of Western Ontario, London, ON

‡‡Rotman Research Institute, Baycrest Departments of Medicine (Neurology Division) and Psychiatry (Geriatric Psychiatry Division), University of Toronto, Canada

Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL

§§Department of Neurology and Center for Neuroscience, Alzheimer's Disease Center and Imaging of Dementia and Aging (IDeA) Laboratory, University of California at Davis

∥∥Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD

¶¶Department of Neurology, University of Pennsylvania, Philadelphia, PA

Funded by NIH/NIA grants PO1-AG019724, P50-AG-03-006, California DHS grants no. 0435514, no. 03-75271 and The Larry Hillblom Foundation, grant no. 2002/2F.

Reprints: Katya Rascovsky, PhD, UCSF Memory and Aging Center, 350 Parnassus Ave, Suite 706, San Francisco, CA 94117 (e-mail:

© 2007 Lippincott Williams & Wilkins, Inc.