Article: PDF OnlyVitamin E and Vitamin C Supplement Use and Risk of Incident Alzheimer DiseaseMorris, Martha Clare; Beckett, Laurel A.; Scherr, Paul A.*; Hebert, Liesi E.; Bennett, David A.; Field, Terry S.†; Evans, Denis A. Author Information Rush Institute for Healthy Aging and Rush Alzheimer's Disease Center, Rush University and Rush-Presbyterian-St.Luke's Medical Center, Chicago, Illinois. U.S.A. *Aging Studies Branch. National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, U.S.A. †Department of Preventive Medicine, Department of Medicine. Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, Boston. Massachusetts, U.S.A. Alzheimer Disease & Associated Disorders 12(3):p 121-126, September 1998. Buy Abstract Oxidative stress may play a role in neurologic disease. The present study examined the relation between use of vitamin E and vitamin C and incident Alzheimer disease in a prospective study of 633 persons 65 years and older. A stratified random sample was selected from a disease-free population. At baseline, all vitamin supplements taken in the previous 2 weeks were identified by direct inspection. After an average follow-up period of 4.3 years, 91 of the sample participants with vitamin information met accepted criteria for the clinical diagnosis of Alzheimer disease. None of the 27 vitamin E supplement users had Alzheimer disease compared with 3.9 predicted based on the crude observed incidence among nonusers (p = 0.04) and 2.5 predicted based on age, sex, years of education, and length of follow-up interval (p = 0.23). None of the 23 vitamin C supplement users had Alzheimer disease compared with 3.3 predicted based on the crude observed incidence among nonusers (p = 0.10) and 3.2 predicted adjusted for age, sex, education, and follow-up interval (p = 0.04). There was no relation between Alzheimer disease and use of multivitamins. These data suggest that use of the higher-dose vitamin E and vitamin C supplements may lower the risk of Alzheimer disease. © 1998 Lippincott Williams & Wilkins, Inc.