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Intramedullary Amputation Neuromas Associated With Spinal Ependymomas

Johnson, Michael W. MD, PhD; Burger, Peter C. MD

The American Journal of Surgical Pathology: April 2009 - Volume 33 - Issue 4 - p 639-643
doi: 10.1097/PAS.0b013e31818fe3c9
Original Articles

We report 5 spinal intramedullary masses containing combined ependymoma and traumatic neuroma. The ependymomas, grade II “cellular” types, were intermixed with or separate from wavy, vaguely fascicular tissue that contained multiple axons immunoreactive for neurofilament protein. The neuromas presumably arose from small perivascular nerve twigs that have been implicated in the pathogenesis of intramedullary neuromas in non-neoplastic spinal diseases. Pathologists should be aware of this distinctive intramedullary tissue that is not to be confused with a neoplasm.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD

Presented in part at the Annual Meeting of The American Association of Neuropathologists, April 28, 2007.

Correspondence: Michael W. Johnson, MD, PhD, Department of Pathology, Johns Hopkins University, 600 N. Wolfe Street, Pathology 710, Baltimore, MD 21287 (e-mail:

© 2009 Lippincott Williams & Wilkins, Inc.