Molecular Profiling of Mammary Analog Secretory Carcinoma Revealed a Subset of Tumors Harboring a Novel ETV6-RET Translocation: Report of 10 Cases : The American Journal of Surgical Pathology

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Molecular Profiling of Mammary Analog Secretory Carcinoma Revealed a Subset of Tumors Harboring a Novel ETV6-RET Translocation

Report of 10 Cases

Skalova, Alena MD, PhD*,†; Vanecek, Tomas PhD‡; Martinek, Petr PhD‡; Weinreb, Ilan MD§; Stevens, Todd M. PhD∥; Simpson, Roderick H.W. MD, MB, ChB, FRCPath¶; Hyrcza, Martin MD, PhD#; Rupp, Niels J. MD**; Baneckova, Martina MD*,†; Michal, Michael Jr MD*,††; Slouka, David MD, MBA, PhD‡‡; Svoboda, Tomas MD, PhD§§; Metelkova, Alena MD, PhD∥∥; Etebarian, Arghavan DDS, OMP¶¶; Pavelka, Jaroslav PhD‡,##; Potts, Steven J. PhD***; Christiansen, Jason PhD***; Steiner, Petr MSc*,‡; Michal, Michal MD*

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The American Journal of Surgical Pathology 42(2):p 234-246, February 2018. | DOI: 10.1097/PAS.0000000000000972

Abstract

ETV6 gene abnormalities are well described in tumor pathology. Many fusion partners of ETV6 have been reported in a variety of epithelial, mesenchymal, and hematological malignancies. In salivary gland tumor pathology, however, the ETV6-NTRK3 translocation is specific for (mammary analog) secretory carcinoma, and has not been documented in any other salivary tumor type. The present study comprised a clinical, histologic, and molecular analysis of 10 cases of secretory carcinoma, with typical morphology and immunoprofile harboring a novel ETV6-RET translocation.

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